What is
diabetic
macular edema?

Diabetic macular edema (DME) is a condition caused by diabetes that can lead to distorted vision or vision loss. When you have DME, damage in your eye due to diabetes can cause the growth of new blood vessels. These blood vessels leak fluid into the part of the eye called the macula.

The macula is responsible for central vision, which is what you use to do things like drive or read. Fluid buildup causes swelling in the macula, which distorts your vision.

Inside an eye with DME

Diagram showing untreated DME

The effects of fluid

Even before you notice vision problems, fluid buildup may be causing damage to your eye. This fluid may lead to distorted vision.

Your doctor may use a scan called an optical coherence tomography (OCT) at every appointment to monitor your eyes. An OCT scan reveals a detailed picture of your retina, so your doctor can see if there is fluid in the back of your eye. Over time, your doctor will track your treatment progress to see if there is more, less, or the same amount of fluid.

Who’s at risk for developing DME?

Certain factors have been found to put people at greater risk for developing DME, such as:

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Living with diabetes for a number of years

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High blood sugar over a long period of time

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High blood pressure and cholesterol

How can DME change your vision?

DME can cause vision changes that may impact your everyday life, such as difficulty reading, driving, and recognizing faces.

Click the tabs to explore the different types of vision changes. Drag the slider to see the varying symptoms.

Central
vision

Lines

Colors

Blurry or blind spots can appear in the center of your vision
Blurry or blind spots can appear in the center of your vision

Blurry or blind spots can appear in the center of your vision.

Straight lines can look bent or wavy.
Straight lines can look bent or wavy.

Straight lines can look bent or wavy.

Colors can look faded and/or washed out.
Colors can look faded and/or washed out.

Colors can look faded and/or washed out.

The progression of DME and associated symptoms affect everyone differently. If you're experiencing any of these symptoms, contact your doctor right away.

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INDICATIONS

IMPORTANT SAFETY INFORMATION

IMPORTANT SAFETY INFORMATION

COLLAPSE

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BEOVU® (brolucizumab-dbll) injection is used for the treatment of Neovascular (Wet) Age-related Macular Degeneration (AMD) and Diabetic Macular Edema (DME).

You should not use BEOVU if you have an infection in or around the eye, eye inflammation, or if you are allergic to brolucizumab or any of the ingredients in BEOVU.

BEOVU is a prescription medicine given by injection into the eye. Injections in the eye, including BEOVU, may cause an infection of the eye or retinal detachment (separation of retina from the back of the eye). It is important to contact your doctor right away if your eye becomes red, sensitive to light, painful, or you develop any change in your vision.

Increased eye pressure has been seen within 30 minutes of an eye injection, including BEOVU. Sustained increases in eye pressure also have been reported. Your doctor should monitor for this when you receive a BEOVU injection.

There is a potential risk of stroke, heart attack, or blood clots in patients receiving eye injections of vascular endothelial growth factor (VEGF) inhibitor drugs, including BEOVU. Sudden vision loss due to blockage of the blood vessels in the back of the eye and inflammation of blood vessels in the back of the eye have been reported.

The most common side effects reported in patients receiving BEOVU in the wet AMD studies were reduced clarity in vision, cataract, broken blood vessels in the eye, eye pain, and vitreous floaters (moving spots in the field of vision). The most common side effect reported in patients receiving BEOVU in the DME studies was broken blood vessels in the eye.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1‑800‑FDA‑1088.

Please see full Prescribing Information.

INDICATIONS

BEOVU® (brolucizumab-dbll) injection is used for the treatment of Neovascular (Wet) Age-related Macular Degeneration (AMD) and Diabetic Macular Edema (DME).